Proton Pump Inhibitors: Pantoprazole is the safe drug as compared to Omeprazole drug during treatment of Dyslipidemia.

Abstract

Introduction: Proton pump inhibitors (PPIs) are commonly used to manage ret-rosternal burning to peptic ulcer disease. Dyslipidemia is also very common in Asian population.
Objective: To evaluate the effects of different groups of PPIs like omeprazole, Pan-toprazole, esomeprazole on lipid profile.
Methodology: This animal study conducted at the Department of Pharmacology with collaboration of Diagnostic & Research laboratory of Liaquat University of Medical & Health Sciences Jamshoro from 16 Nov to 30 Nov 2020. 24 male rabbit were divided in 3 equal groups. The sample for lipid profile were taken twice; first sample was collected before start of PPPIs, while another sample was taken after six weeks of the treatment with different groups of PPPIs. The lipid profile was ana-lyzed by Cobass Auto analyzer (C-311) of Hitachi at Diagnostic & Research Labora-tory LUMHS. The Statistical analysis was performed by student ‘t’ test and chi square test by using SPSS version 21.
Result: The results found were statistically significant (p=<0.05) for omeprazole and esomeprazole while it was insignificant (p=0.247) for pantoprazole. TG’s was signifi-cantly more in group A and B animals as compare to group C animals. Low density Lipoprotein found raised among all groups but the rise was statistically insignifi-cant.
Conclusion: Omeprazole exerts significant effects over all observed parameters of lipid profile, esomeprazole showed effects over few parameters, while pantopra-zole showed insignificant effects over lipid profile.
Key words: Proton Pump Inhibitors, Low density Lipoprotein, Cholesterol.