Anti-hyperglycemic effects of Aescin at different doses: An experimental animal study.

Abstract

Objective: To determine the effects of Aescin on blood glucose homeostasis in fructose fed Diabetic albino Wistar rats.
Methodology: Quasi Experimental study was conducted at the Department of Pharmacology from September 2020 to March 2021. Fifty albino Wistar rats were equally divided into five groups according to dose as; Group A (normal diet), Group B (Fructose 10 g/kg/day), Group C (Fructose 10 g/kg/day plus aescin0.9 mg/kg/day), Group D (Fructose 10 g/kg/day plus aescin1.8 mg/kg/day) and Group E (Fructose 10 g/kg/day plus aescin3.6 mg/kg/day). Post-experimental body weight was measured after completion of four weeks. While blood samples were also collected from all
animals to assess the blood glucose level and serum insulin level at the end of experiment duration. Data was analyzed using SPSS version 20.
Results: Mean blood glucose in control group A (165.0±14.29 mg/dL) was significantly (p<0.05) lower in contrast to experimental groups B, C and D (357.17±21.73, 246.08±21.73 and 235.67±25.73 respectively) while no significant difference observed between group A and group E (194.0±22.16 mg/dl). Serum insulin level was significantly lower (p<0.05) in experimental group B (17.45± 5.17) as compared to control group A (16.88± 4.78). Mean serum insulin level in Aescin administrated (group E, 3.6 mg/kg/day) was significantly higher (p<0.05) (29.10± 1.64 IU/L) as
compared control and other experimental groups.
Conclusion: The Aescin exerts the ameliorating effects on glucose homeostasis; by its administration serum insulin level also increases that may help to control diabetes.
Keywords: Aescin, Fructose, Glucose Homeostasis, Insulin.