Association of Hypertension with serum ferritin level in local population of Mirpurkhas.

Abstract

Introduction: Raised serum ferritin causes disturbance in the body metabolism leading to dyslipidemia, adiposity and hypertension.

Objective: is to investigate the ferritin level and its possible effects on arterial blood pressure of local population.

Methodology: This prospective, case control study was conducted during June 2017 to November 2018 in the Department of Physiology, Muhammad Medical College; Mirpurkhas Sindh after taking approval from ethical review committee. 50 hypertensive patients without any comorbid of either genders and an equal number of healthy age and sex matched controls were included in the study. Arterial pressure was measured by mercuric sphygmomanometer using standard method while serum ferritin was estimated by ELISA.

Results: The mean age of patients was 55.2 ±11.14, and of controls was 47.12 ±14.29. The mean BMI of patients was 24.27 ±3.347 and of controls was 24.71±2.57. The difference in mean systolic blood pressure of patients (129.90 ±17.2mmHg), and controls (118.80 ±11.89) was statistically significant (p=0.013). Similarly, the mean diastolic blood pressure of patients was 83.60 mmHg ± 10.83 and for controls it was 76.40 ±7.63 with significant difference (p=0.025). The difference between mean serum ferritin level of patients (226.32±99.83) and controls (224.0 ±69.62) was also statistically significant (p=0.001). The correlation coefficient was statistically significant showing r value of ferritin with diastolic pressure r ═ 0.14, with systolic pressure r = 0.16 and with hypertension (both systolic and diastolic pressures) r = 0.21.

Conclusion: This study showed significant association of Hypertension with serum ferritin.

Keywords: Ferritin, BMI, Hypertension.