Levels of Fructose-2,6-Bisphosphate in Lymphocytes of Diabetic Patients.

Abstract

Background: Patients with diabetes mellitus have infections more often than those without diabetes. Several
factors predispose diabetic patients to infections, including an alteration in immune defense mechanism. Elevated levels of fructose-2,6- bisphosphate in lymphocyte have been shown in diabetic patients. The activation of
glycolysis by fructose -2,6- bisphosphate in peripheral blood mononuclear cells causes the accumulation of glycolytic metabolites and inhibits the activation of immune cells.
Objective: To observe and compare the levels of fructose-2,6-bisphosphate in lymphocytes of diabetics and normal subjects
Material and Methods: 200 diabetic and 50 control subjects were selected for study .The subjects were evaluated for severity of diabetes and their fasting blood glucose, HbA1C, total leucocyte count, lymphocyte count and
fructose-2,6-bisphosphate in lymphocytes were estimated.
Results: The results show that mean fasting blood glucose, HbA1C, total leucocytes count and fructose-2,6-
bisphosphate levels in lymphocytes were significantly higher (P<0.001) while lymphocyte count was significantly
lower (P<0.001) in diabetic patients as compared to control group.
Conclusions: It was concluded from the facts observed in this study that elevated levels of fructose-2,6-
bisphosphate in lymphocytes and decreased number of lymphocytes may have induced chances of infections in
diabetic patients.
Keywords: Lymphocytes, Fructose-2,6-bisphosphate, Diabetes, Infections.