Morphological and Histological Changes in Placentae of Hypertensive Women.

Abstract

Objective: To determine the changes in placentae in pregnant ladies suffering from pregnancy induced Hypertension.
Research Design: A cross sectional study
Place and duration: Sampling was done of the patients from the OPD’s of Taluka hospital Hala and basic health
unit Hala old, with collaboration of department of Anatomy, Baqai Medical University, Karachi, from june-2011-
Dec- 2011
Material and Methods: Placentae were preserved in 10% formalin of Merck Company and studied macroscopically as well as microscopically. These features include shape, size, and site of attachment of umbilical cord,
central thickness and diameter (in centimeter, diameters) and weights (in grams) of fully developed placentae.
Microscopic feature will include infarction, placental haemorrhage, villous edema, hyper vascularity and increase
production of syncytial epithelial knots.
Results: Central thickness (Mean ± S.D ± SEM) of hypertensive placenta 2.2 ± 0.58 ± 0.11 were significantly
less (p<0.01) as compared to normal placenta 3.0 ± 0.03 ± 0.01. Hypertensive placenta diameter 19.5 ± 5.10 ±
0.93), weight 524.4 ± 154.7 ± 28.4.
Conclusion: Eclampsia causes significant morphological changes in placenta that affects fetal and maternal
wellbeing. This study is helpful for those who are concerned for mother and child health.
Keywords: Placentae, Eclampsia, Macroscopy, Microscopically.