Correlation between Glycosylated Hemoglobin level with Angiographic findings of Coronary Artery Disease in different ages.

Abstract

Objective: Coronary Artery Disease (CAD) is one of major macro vascular complication of Diabetes Mellitus (DM). The object of study is to analyze the correlation of angiographic findings of CAD with changes of glycosylated Hemoglobin (HbA1c) levels in CAD Patients, T2DM Patients and Patients having both CAD and T2DM as compared to normal in different age groups.
Methodology: This cross-sectional descriptive study was conducted at Rawalpindi Institute of Cardiology (RIC) during 1st December 2020 to 28th February 2021. The study included 1540 (385 subjects in each group) from Rawalpindi Institute of Cardiology hospital presenting with symptoms of CAD. A Complete demographic data was taken. They were assessed according to HbA1c level and type of CAD based on angiographic findings. Patients were divided into 4 groups according to HBA1C ranging from <5 % to > 8.0% and 4 age groups ranging from 40 to 79 years.
Result: A statistical positive correlation between HBA1c with advancing age. Most vulnerable age group was 50-59 years in all groups of altered HBA1c. A statistical correlation between Angiography findings of CAD with HBA1c was significantly positive. (p<0.001).
Conclusion: HbA1c can be used as a predictor of severity of coronary artery disease measured by Angiographic findings as patients with a higher level of HbA1c had significant severe lesions on Angiography.

Keywords: Coronary heart disease, type 2 Diabetes Mellitus, HbA1c, Angiographic findings in CAD.