A study of the antibiotic resistance trajectory of clinical bacterial infections obtained from patients in Govt hospital

Abstract

Objective: This research emphasizes on analyzing resistance pattern in bacteria, all samples are taken at the District Health Quarter in Hyderabad and the Rural Health Center in Mirpur Khas.
Methodology: All the results related to antibiotic susceptibility and microbiological cultures from different patients sam-ples submitted to the EPHI laboratory between September 2015 and August 2019 were analyzed through a retrospec-tive cross-sectional study. Microbial isolates were isolated and identified by using state of the art microbiological ma-chines and after that characterization of all samples done by using standard bacteriological methods. Information on the type of clinical specimen cultured, the bacterial species identified, the antibiotics employed for susceptibility testing, and the corresponding susceptibility outcomes were all extracted from the records of 840 patients.
Results: The bacterial isolates and patterns of antibiotic resistance were explained using statistical techniques. Eight categories of clinical samples were analyzed for the presence of bacterial isolates with blood specimens being the most thoroughly examined. Thirteen distinct bacterial genera were found by culturing. Almost 80% of the isolates belonged to the Gram-negative group of bacteria., but three gram-positive species (Enterococcus, Staphylococcus aureus, and MRSA) were identified. Antimicrobial susceptibility testing of seventy isolates showed higher resistance in Escherichia coli than in other species.
Conclusion: This study revealed worrying rates of multidrug resistance. antibiotic resistance surveillance must be strengthened nationally, and antibiotic sensitivity testing in community-level diagnostic centers is highly recommended.
Key words: Sensitivity pattern, Antibiotic resistance, Clinical bacterial infections, Govt Hospital