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Introduction: Since H. Pylori has been isolated in stomach and duodenum, there were individual methodologies to explain the grading according to colonization and density of microorganism. In 1990 Sydney system of classification was proposed at the 9th world congress of gastroenterology in Sydney Australia, based on topo-graphical, morphological and etiological findings. This classification revised in 1994 and updated by experts in Houston Texas. H. Pylori is major cause of chronic gastri-tis results in gastric and peptic ulcer. It also causes MALT lymphoma and malignan-cy. For histopathological examination four specimens, two from antrum and two from corpus are recommended.
Objective: To evaluate the Sydney system of classification and grading for H. Pylori in local population.
Methodology: 287 cases of biopsies received at the department of pathology Mu-hammad Medical College, Mirpurkhas Sindh Pakistan, during the period of January 2017 to December 2018 were revised. Sections stained with Hematoxylin and Eosin; Alcian blue and periodic acid Schiff to define H. Pylori and associated pathological changes. The microscopical findings classified according to upgraded Sydney pattern.
Results: Out of 287 cases of gastric biopsies 23 (8.0%) were positive for H. Pylori. chronic inflammation present in 168 (58.5%). Neutrophilic activity found in 58 (18.1%). Atrophy without metaplasia observed in 31 (10.8%). Intestinal metaplasia present in 1 (0.3%) cases.
Conclusion: Sydney system of grading is best to evaluate chronic gastritis and relia-ble indicator of H. Pylori microorganism.
Keywords: Chronic gastritis, Gastric carcinoma. H. Pylori.
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