HYPER CHELOSTROLEMIA AS A RISK FACTOR FOR TYPE 2 DIABETIC RETINOPATHY.

Abstract

Introduction: Diabetes mellitus encompasses a family of disorders of carbohydrate metabolism that are characterized by hyperglycemia in the development of long-term macro vascular, micro vascular and neuropathic complication.
Methodology: A retrospective study was done in diabetic clinic attached with medical unit-ill (Ward 7), JPMC,
Karachi. 100 consecutive patients between the ages of 40-70 years, who attended the diabetic clinic with type 2
Diabetes between Decembers 2002 to April 2003 had a Funduscopic examination to see the presence of diabetic
retinopathy. Lipid profile was done to see the correlation between hypercholesterolemia, hypertriglyceridemia,
raised LDL and raised HDL and diabetic nephropathy. SPSS version 10 was used to see the statistic correlation,
evaluated by relative risk and linear regression and correlation analyzed.
Results: Statistically significant positive correlation was found of diabetic retinopathy with hypercholesterolemia,
hypertriglyceridemia and raised LDL and statistically significant negative correlation was found between diabetic
retinopathy and raised HDL.
Conclusion: In diabetic patients, hypercholesterolemia, hypertriglyceridemia and raised LDL predispose to retinopathy and raised HDL prevents against diabetic retinopathy.
Keywords: Diabetes Retinopathy, hypercholesterolemia, hypertriglyceridemia, LDL, HDL.